What is TB-500 (Thymosin Beta-4) and how does it relate to actin dynamics?

TB-500 is a synthetic version of Thymosin Beta-4, one of the most abundant peptides in mammalian cells. It regulates actin polymerization, which drives cell migration and wound healing. Research shows it promotes keratinocyte and endothelial cell migration, stimulates angiogenesis, and reduces inflammation in preclinical models.

TB-500 is a synthetic version of the 43-amino acid peptide Thymosin Beta-4 (Tβ4), one of the most abundant peptides in mammalian cells. Its primary structural role is the sequestration of globular actin (G-actin), which regulates actin polymerization dynamics essential for cell migration, proliferation, and wound healing. Research has demonstrated that Tβ4 promotes the migration of keratinocytes and endothelial cells into wound sites, stimulates angiogenesis, and reduces inflammation via down-regulation of nuclear factor kappa-B (NF-κB) signaling. In cardiac injury models, exogenous Tβ4 has been shown to activate epicardial progenitor cells.

Source: Ann N Y Acad Sci (2012) · PubMed

TB-500 — 5mg, 99.22% purity →

Summarised from peer-reviewed literature for research reference. For laboratory research use only.