What is BPC-157 and what biological mechanisms have been studied?

BPC-157 is a synthetic 15-amino-acid peptide derived from a protein in human gastric juice. Preclinical research has studied its effects on angiogenesis, nitric oxide signaling, and tissue repair, with rodent studies reporting accelerated tendon, muscle, and gastrointestinal healing. Human clinical data remain limited.

BPC-157 (Body Protective Compound-157) is a synthetic pentadecapeptide derived from a protein found in human gastric juice. Research has examined its effects on angiogenesis, nitric oxide synthesis, and growth factor receptor modulation. Proposed mechanisms include upregulation of vascular endothelial growth factor (VEGF), interaction with the NO-system to promote vasodilation, and modulation of the dopaminergic and serotonergic neurotransmitter systems. Preclinical studies across rodent models report accelerated tendon-to-bone healing, muscle injury repair, and gastroprotective effects, though human clinical data are limited.

Source: Curr Pharm Des (2018) · PubMed

BPC-157 — 5mg, 99.27% purity →

Summarised from peer-reviewed literature for research reference. For laboratory research use only.